Mechanisms of interaction between the sulfhydryl precursor L-methionine and glyceryl trinitrate.

Mechanisms of interaction between the sulfhydryl precursor L-methionine and glyceryl trinitrate.

BACKGROUND L-Methionine potentiates systemic hemodynamic effects of intravenous glyceryl trinitrate (GTN) in tolerant and nontolerant patients to a similar extent as N-acetylcysteine (NAC). This potentiation of GTN action by L-methionine has been attributed to enhanced intracellular formation of nitrosothiols, known to be potent stimulators of soluble guanylyl cyclase. This study was performed ...

Comparison with glyceryl trinitrate

The coronary haemodynamic effects of nifedipine and glyceryl trinitrate were compared in 22 patients undergoing investigations for suspected coronary artery disease. Myocardial blood flow was estimated by the coronary sinus thermodilution technique. In sinus rhythm nifedipine increased mean coronary sinus flow from 135 ml/min to 152 m/min, and reduced arterio-coronary sinus oxygen difference fr...

Glyceryl trinitrate before coronary angiography.

Patients' knowledge of sublingual glyceryl trinitrate.

of stones from the gall bladder.3 There are several clinical implications. The long contiguous course of the cystic duct and common hepatic duct could explain why surgeons sometimes inadvertently leave a long remnant of cystic duct, which is reputedly a cause of the postcholecystectomy syndrome.4 Furthermore, the migration of stones from the gall bladder into the contiguous segment may explain ...

the investigation of the relationship between type a and type b personalities and quality of translation

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